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Comparison of Pulmonary Responses of Asthmatic and Nonasthmatic Subjects Performing Light Exercise While Exposed to a Low Level of Ozone

U.S. Environmental Protection Agency National Health and Environmental Effects Research Laboratory Human Studies Division Research Triangle Park, North Carolina

Beth A. Ball

University of North Carolina, Center for Environmental Medicine and Lung Biology Chapel Hill, North Carolina

James Brown

University of North Carolina, Center for Environmental Medicine and Lung Biology Chapel Hill, North Carolina

Timothy Gerrity

Department of Veterans Affairs Medical Research Service Washington, D.C.

Lawrence J. Folinsbee

U.S. Environmental Protection Agency National Health and Environmental Effects Research Laboratory Human Studies Division Research Triangle Park, North Carolina

To determine if asthmatic subjects (ASTH, n = 17) experience greater O₃ induced pulmonary decrements than nonasthmatic subjects (NONA, n = 13), both groups were exposed for 7.6 h to both clean air and 0.16 ppm 03. Exposures consisted of seven 50-min periods of light exercise (VE = 14.2 and 15.3 l/min/m² for ASTH and NONA, respectively), each followed by 10 min rest. A 35-min lunch period followed the third exercise. Following 03 exposure, decrements in forced expiratory volume in one second (FEV₁) and FEV₁ divided by forced vital capacity (FVC), corrected for air exposure, for ASTH

Toxicology and Industrial Health, Vol. 11, No. 4, 369-385 (1995)
DOI: 10.1177/074823379501100401


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