This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Werley, M. S. Articles by Ballantyne, B. Search for Related Content PubMed Articles by Werley, M. S. Articles by Ballantyne, B. Social Bookmarking                         What's this?

Respiratory Peripheral Sensory Irritation and Hypersensitivity Studies With Glutaraldehyde Vapor

Bushy Run Research Center Union Carbide Corporation Export, Pennsylvania

Heather D. Burleigh-Flayer

Bushy Run Research Center Union Carbide Corporation Export, Pennsylvania

Bryan Ballantyne

Bushy Run Research Center Union Carbide Corporation Export, Pennsylvania

Overexposure to glutaraldehyde (GA) vapor (CAS No. 111-30-8) is known to cause peripheral sensory irritant effects in humans. Respiratory sensory irritation was investigated in male ND4 Swiss Webster mice to quantify the effect, and also as a preliminary to a study of the respiratory sensitizing potential of GA. For the irritation study, groups of four mice were exposed to seven different GA vapor concentrations in the range of 1.6 to 36.7 ppm, while respiratory rate (RR) was measured by plethysmography. Concentration-related decreases in RR were measured, with a maximum decrease at 3 to 20 min, which was sustained, indicating an absence of desensitization. The 50% decrease in RR (RD50) was calculated to be 13.9 ppm, which accords with the known sensory irritancy of GA and other aliphatic aldehydes. In a separate study, the respiratory sensitizing potential of GA vapor was studied in male Hartley guinea pigs, who were exposed for one hour per day for five consecutive days to an inducing GA vapor concentration of 13.9 ppm. Subsequent challenge exposures to 4.4 ppm at 14, 21, and 35 days after the final induction exposure did not produce any evidence of respiratory sensitization. The above findings confirm that GA vapor is a moderately potent peripheral sensory irritant, and does not produce respiratory sensitization in the guinea pig at the concentrations tested.

Key Words: RD50 • depression of respiratory rate by 50% • GC/MS • gas chromatography-mass spectroscopy • GA • glutaraldehyde • MBTH • 3-methyl-2-benzothiazolinone hydrazine • NMR • nuclear magnetic resonance • PSI • peripheral sensory irritant • RR • respiratory rate.

Toxicology and Industrial Health, Vol. 11, No. 5, 489-501 (1995)
DOI: 10.1177/074823379501100503


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?