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The National Exposure Registry: Analyses of Health Outcomes From the Benzene Subregistry

Agency for Toxic Substances and Disease Registry Public Health Service Department of Health and Human Services Atlanta, Georgia

Ginger L. Gist

Agency for Toxic Substances and Disease Registry Public Health Service Department of Health and Human Services Atlanta, Georgia

The purpose of the National Exposure Registry is to assess the long-term health consequences to a general population from long-term, low-level exposures to specific substances in the environment. This study investigates the health outcomes of 1, 143 persons (1,127 living, 16 deceased) living in south central Texas who had documented environmental exposure to benzene (up to 66ppb) in tap water. As with all subregistries, face-to-face interviews were used to collect self-reported information for 25 general health status questions. Using computer-assisted telephone interviewing, the same health questions were asked I year (Followup 1, F1) and 2 years later (Followup 2, F2). The health outcome rates for Baseline and Followup I and 2 data collections for the Benzene Subregistry were compared with national norms, that is, the National Health Interview Survey (NHIS) rates. For at least one of the three reporting periods, specific age and sex groups of the Benzene Subregistry population reported more adverse health outcomes when compared with the NHIS population, including anemia and other blood disorders, ulcers, gall bladder trouble, and stomach or intestinal problems, stroke, urinary tract disorders, skin rashes, diabetes, kidney disease, and respiratory allergies. Statistically significant deficitsfor the Benzene Subregistry population overall were found for asthma, emphysema, or chronic bronchitis; arthritis, rheumatism, or other joint disorders; hearing impairment; and speech impairment. No statistically significant differences between the two populations were seen for the outcomes hypertension; liver disease; mental retardation; or cancer. These results do not identify a causal relationship between benzene exposure and adverse health effects; however, they do reinforce the need for continued followup of registrants.

Key Words: 2. Abbreviations: ATSDR • Agency for Toxic Substances and Disease Registry • BL • Baseline • CER • Comprehensive Environmental Response • CI • confidence interval • F1 • Followup 1 • F2 • Followup 2;NCHS • National Center for Health Statistics • NER • National Exposure Registry • NHIS • National Health Interview Survey • NHSDA • National Household Survey on Drug Abuse • NPL • National Priority List • O/E • observed/ expected • ppb • parts per billion • SIR • standardized incidence ratio • SMR • standardized mortality ratio • TCR • Texas Cancer Registry.

Toxicology and Industrial Health, Vol. 14, No. 3, 367-387 (1998)
DOI: 10.1177/074823379801400301


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