This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wright, R. O. Articles by Shannon, M. W. Search for Related Content PubMed PubMed Citation Articles by Wright, R. O. Articles by Shannon, M. W. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB LEAD, ELEMENTAL Social Bookmarking                         What's this?

Effect of Iron Deficiency Anemia On Lead Distribution After Intravenous Dosing in Rats

Department of Medicine Boston Children's Hospital Boston, Massachusetts, wright_r{at}al.tch.harvard.edu, The Channing Laboratory Brigham and Women's Hospital Boston, Massachusetts

Howard Hu

Division of Occupational Medicine and Environmental Health Sciences Harvard School of Public Health Cambridge, Massachusetts, The Channing Laboratory Brigham and Women's Hospital Boston, Massachusetts

Timothy J. Maher

Harvard Medical School Massachusetts College of Pharmacy and Allied Health Sciences Boston, Massachusetts

Chitra Amarasiriwardena

Division of Occupational Medicine and Environmental Health Sciences Harvard School of Public Health Cambridge, Massachusetts, The Channing Laboratory Brigham and Women's Hospital Boston, Massachusetts

Pasarapa Chaiyakul

Harvard Medical School Massachusetts College of Pharmacy and Allied Health Sciences Boston, Massachusetts

Alan D. Woolf

Department of Medicine Boston Children's Hospital Boston, Massachusetts

Michael W. Shannon

Department of Medicine Boston Children's Hospital Boston, Massachusetts

Objective: To determine the effect of iron deficiency anemia on blood and tissue lead distribution.Methods: 24 weanling rats were divided into 2 groups. One group received an iron replete diet (200 ppm); the other received a low iron diet (20 ppm). After 24 days, each group was further subdivided into two doses of lead (5 mg/kg and 10 mg/kg) which was administered intravenously. Rats were continued on their respective diets for 7 days post-lead injection to allow tissue distribtrtion, then sacrificed and blood and tissue lead concentration measured. Results: Prior to lead administration, baseline blood lead concentrations were not significantly different between groups. At sacrifice, whole blood lead levels were significantly higher in iron deficient animals than in iron replete at both 5 and 10 mg/kg administered lead. Iron deficient animals had comparable lead concentrations to iron replete animals in brain, kidney and liver. Femur lead concentrations were higher at 10 mg/kg administered lead. Conclusion: Iron deficiency alters lead distribution such that increased lead is found in blood for a given exposure.

Key Words: hypochromic anemia • iron • iron deficiency • lead • lead poisoning.

Toxicology and Industrial Health, Vol. 14, No. 4, 547-551 (1998)
DOI: 10.1177/074823379801400405


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?