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Toxicology and Industrial Health, Vol. 15, No. 3-4, 410-414 (1999)
DOI: 10.1177/074823379901500315

Psychiatric illness in the first-degree relatives of persons reporting multiple chemical sensitivities

Donald W. Black

Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242-1000

Christopher Okiishi

University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1000

Janelle Gabel

Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242-1000

Steven Schlosser

Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242-1000

The multiple chemical sensitivities (MCS) syndrome is characterized by unexplained physical and psychiatric complaints attributed by patients and some of their physicians to low-level chemical exposures. In this study, we interviewed 15 subjects with MCS and 21 controls about their first-degree relatives using the Family History-Research Diagnostic Criteria (FH-RDC). Subjects with MCS were more likely than controls to report their relatives to have major depression, alcoholism, panic disorder, obsessive-compulsive disorder, and antisocial personality disorder. They were also likely to have past suicide attempts, and to have received some form of psychiatric treatment (hospitalization, medication or electroconvulsive therapy, or counseling). Nearly 30% of the relatives of subjects with MCS were reported to have MCS themselves. Possible reasons for the findings are discussed.


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