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Toxicology and Industrial Health
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Site-specific consultation for a chemical mixture

H. R. Pohl

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

N. Roney

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

M. Fay

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

C.-H. S.J. Chou

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

S. Wilbur

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

J. Holler

Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

The Agency for Toxic Substances and Disease Registry (ATSDR) uses the weight of evidence methodology to evaluate interactions of chemical mixtures. In the process, toxicity, toxicokinetics, and toxicodynamics of chemical components of the mixture are carefully examined. Based on the evaluation, predictions are made that can be used in real-life situations at hazardous waste sites. In this paper, health outcomes were evaluated for a mixture of eight compounds that were found at a specific site. These eight chemicals were identified and possibly associated with human exposure. The health assessors could consider similar thought processes when evaluating chemical mixtures at hazardous waste sites.

Toxicology and Industrial Health, Vol. 15, No. 5, 470-479 (1999)
DOI: 10.1177/074823379901500502
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This article has been cited by other articles:


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S. Krimsky
The Weight of Scientific Evidence in Policy and Law
Am J Public Health, July 1, 2005; 95(S1): S129 - S136.
[Abstract] [Full Text] [PDF]


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