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Toxicology and Industrial Health
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Cardiovascular effects of odors

Carr J. Smith

Research and Development, R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Sandra M. Scott

Research and Development, R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Brett A. Ryan

Research and Development, R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Several occupational and residential settings can expose both normal and sensitive human subjects to odors and irritants. These settings include intensive agricultural operations housing swine and poultry, cigarette-smoke-filled bars, landfills and manufacturing processes. The literature suggests that adverse sensory reactions to strong odors and irritants may lead to the release of catecholamines and stress hormones. Physiological and biochemical measurements related to cardiovascular risk, e.g., blood pressure, heart rate, high-density lipoprotein (HDL) cholesterol level and serum triglyceride level, may be altered as a result of exposure to odor and irritant-induced release of catecholamines. Further work in the form of field studies and chamber exposure protocols is required to determine whether the physiological and biochemical changes observed to date represent an increase in cardiovascular risk, or are reversible changes within the normal homeostatic range.

Key Words: cardiovascular effect • irritant • odor

Toxicology and Industrial Health, Vol. 15, No. 7, 595-601 (1999)
DOI: 10.1177/074823379901500701


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