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Breast-feeding exposure of infants to selected pesticides: a public health viewpoint

Division of Toxicology, Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

Carolyn A. Tylenda

Division of Toxicology, Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

In this paper, we provide an overview of the public health implications of exposure to some pesticides via breast milk and provide health-based guidance. The presence of organochlorine pesticides in breast milk has been documented in many studies around the world. Included in our review are aldrin/dieldrin, chlordane, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT)/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), endrin, hexachlorobenzene (HCB), and hexachlorocyclohexane (HCH). Toxicological and environmental data on these chemicals are compiled in toxicological profiles published by the Agency for Toxic Substances and Disease Registry (ATSDR). Based on the data, ATSDR derives chemical-specific minimal risk levels (MRLs) that assist in evaluating public health risks associated with exposure. MRLs are health-based guidance values designed to protect the most sensitive populations, including breast-fed infants. We compare MRLs and projected intakes from the breast milk for the listed pesticides, explore the possibilities of toxicological interactions, and provide health-based recommendations.

Key Words: breast milk • developmental effects • pesticides

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