SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Toxicology and Industrial Health
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Edelson, S. B.
Right arrow Articles by Cantor, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Edelson, S. B.
Right arrow Articles by Cantor, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The neurotoxic etiology of the autistic spectrum disorders: a replication study

Stephen B. Edelson

The Edelson Center for Environmental and Preventive Medicine, Inc., 3833 Rowell Road, Suite 110, Atlanta, Georgia 30342, www.edelsoncenter.com

David Cantor

Psychological Sciences Institute, 221 Scenic Highway, Lawrenceville, Georgia, 30045, cantord{at}psycscienceinst.com

Although it has been recognized that autism is a disorder due to dysfunctional central nervous system functioning, a model that can account for the diversity of the symptoms in the syndrome and the concordant anomalies in metabolic functioning, in a sample of 20 autistic individuals, Edelson and Cantor [Edelson S.B., and Cantor D.S. Autism: xenobiotic influences. Toxicol Ind Health 1998: 14 (6): 799-811.] demonstrated a body burden of neurotoxicants in over 90% of these individuals with 100% of these individuals demonstrating impaired liver detoxication processes. This current study examined an independent sample of 39 autistic individuals and was able to replicate the general findings of Edelson and Cantor. We further evidence the genetic and environmental aspects of this hypothetical process and believe the immune system injury secondary to the immunotoxins causes "activation" of the immune system leading to the production of autoantibodies against haptens (brain proteins attached to chemical molecules), and the subsequent damage as part of the process of neurotoxicity in the autistic spectrum. This process has as its final pathway one of free radical generation and molecular injury. This paper can not go into the complex details of this process at this time. All of the above leads to a spectrum of neurodevelopment dysfunction demonstrated as autism.

Toxicology and Industrial Health, Vol. 16, No. 6, 239-247 (2000)
DOI: 10.1177/074823370001600604
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CVIHome page
A. Vojdani, M. Bazargan, E. Vojdani, J. Samadi, A. A. Nourian, N. Eghbalieh, and E. L. Cooper
Heat Shock Protein and Gliadin Peptide Promote Development of Peptidase Antibodies in Children with Autism and Patients with Autoimmune Disease
Clin. Vaccine Immunol., May 1, 2004; 11(3): 515 - 524.
[Abstract] [Full Text] [PDF]


Advertisement