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Toxicology and Industrial Health, Vol. 17, No. 1, 23-29 (2001)
DOI: 10.1191/0748233701th094oa

Age-related differences in pulmonary inflammatory responses to JP-8 jet fuel aerosol inhalation

Shengjun Wang

The Joan B. and Donald R. Diamond Lung Injury Laboratory, Department of Pediatrics, The University of Arizona College of Medicine, Tucson, Arizona, USA

R Scott Young

Department of Cell Biology and Anatomy, The University of Arizona College of Medicine, Tucson, Arizona, USA

Mark L Witten

The Joan B. and Donald R. Diamond Lung Injury Laboratory, Department of Pediatrics, The University of Arizona College of Medicine, Tucson, Arizona, USA

Our previous studies have demonstrated that JP-8 jet fuel aerosol inhalation induced lung injury and dysfunction. To further examine JP-8 jet fuel-induced inflammatory mechanisms, a total of 40 male C57BL/6 mice (young, 3.5 months; adult, 12 months; half in each age group) were randomly assigned to the exposure or control groups. Mice were nose-only exposed to room air or atmospheres of 1000 mg/m3 JP-8 jet fuel for 1 h/day for 7 days. Lung injury was assessed by pulmonary mechanics, respiratory permeability, lavaged cell profile, and chemical mediators in bronchoalveolar lavage fluid (BALF). The young and adult mice exposed to JP-8 jet fuel had similar values with regards to increased lung dynamic compliance, lung permeability, BALF cell count, and decreased PGE2. However, there were several different responses between the young-versus-adult mice with respect to BALF cell differential, TNF-{alpha}, and 8-iso-PGF2{alpha} levels after exposure to JP-8 jet fuel. These data suggest that JP-8 jet fuel may have different inflammatory mechanisms leading to lung injury and dysfunction in the younger-versus-adult mice.

Key Words: inflammatory mediators • JP-8 jet fuel • lung function • respiratory permeability


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