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Toxicology and Industrial Health, Vol. 17, No. 2, 41-62 (2001)
DOI: 10.1191/0748233701th098oa
© 2001 SAGE Publications

Carcinogenic effects of polychlorinated biphenyls

Obaid M Faroon

Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA, oxs0{at}cdc.gov

Sam Keith

Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA

Dennis Jones

Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA

Christopher De Rosa

Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA

As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of an important section of the Toxicological profile for polychlorinated biphenyls [ATSDR. 2000: Toxicological profile for polychlorinated biphenyls. Atlanta, GA: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry.] into the scientific literature. This article focuses on the carcinogenic effects of this group of synthetic organic chemicals (polychlorinated biphenyls) in humans and animals. Information on other health effects, toxicokinetics, mechanisms of toxicity, biomarkers, interactions, chemical and physical properties, potential for human exposure, and regulations and advisories is detailed in the profile.

Key Words: biliary tract cancer • breast cancer • cancer • congener • liver cancer • mixtures • non-Hodgkin’s lymphoma • PCBs • skin cancer


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[Abstract] [PDF]