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Toxicology and Industrial Health, Vol. 17, No. 4, 105-112 (2001)
DOI: 10.1191/0748233701th096oa

Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD

ES Johnson

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA, meatjoh{at}tulane.edu

C Shorter

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA

LL Bestervelt

Toxicology Program, Department of Environmental and Industrial Heath, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA

DG Patterson

Division of Environmental Health and Laboratory Sciences, Centers for Disease Control and Prevention, Mail Stop F17, 4770 Guilford Highway NE, Atlanta, Georgia 30341, USA

LL Needham

Division of Environmental Health and Laboratory Sciences, Centers for Disease Control and Prevention, Mail Stop F17, 4770 Guilford Highway NE, Atlanta, Georgia 30341, USA

WN Piper

Toxicology Program, Department of Environmental and Industrial Heath, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA

G Lucier

Division of Environmental Toxicology, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA

CJ Nolan

Toxicology Program, Department of Environmental and Industrial Heath, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA

We measured current serum hormone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations in 37 men who sprayed 2,4,5- trichlorophenoxyacetic acid (2,4,5-T) in the State of Victoria, Australia. TCDD levels were consistently significantly inversely related to prolactin levels in all analyses. In correlation analyses, TCDD levels were also inversely related to triiodothyronine (T3), thyroid-stimulating hormone (TSH), and testosterone levels, and positively associated with glucagon levels. The mean serum TCDD concentration in these sprayers was between 2.6 and 8.1 parts per trillion (ppt). Since such TCDD levels are commonly found in the general population in countries such as the US, the results could suggest that background levels of TCDD in the general population could have an effect on hormone levels. The findings are preliminary and need to be replicated in order to evaluate their full public health significance.

Key Words: dioxin • hormones • prolactin • sprayers • TCDD • 2,4,5-T


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