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Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA, rhenders{at}lrri.org

Edward B Barr

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Walter B Blackwell

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Connie R Clark

US Army Medical Research Institute of Chemical Defense, Aberdeen, Maryland, USA

Carole A Conn

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Roma Kalra

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Thomas H March

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Mohan L Sopori

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Yohannes Tesfaigzi

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Margaret G Ménache

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Deborah C Mash

University of Miami, Miami, Florida, USA

Karol Dokladny

University of New Mexico, Albuquerque, New Mexico 87108-5127, USA

Wieslaw Kozak

Medical College of Georgia, Augusta, Georgia, USA

Anna Kozak

Medical College of Georgia, Augusta, Georgia, USA

Maceij Wachulec

Medical College of Georgia, Augusta, Georgia, USA

Karin Rudolph

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Matthew J Kluger

Medical College of Georgia, Augusta, Georgia, USA

Shashi P Singh

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Seddigheh Razani-Boroujerdi

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Raymond J Langley

Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Key Words: cholinergic receptors • immne system • nerve gas • sarin

Toxicology and Industrial Health, Vol. 17, No. 5-10, 294-297 (2001)
DOI: 10.1191/0748233701th105oa


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