Toxicology and Industrial Health

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimizu, H.
Right arrow Articles by Kono, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimizu, H.
Right arrow Articles by Kono, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Toxicology and Industrial Health, Vol. 18, No. 8, 389-395 (2002)
DOI: 10.1191/0748233702th163oa

Therapeutic effects of glucose infusion on monochloroacetic acid exposure in rats

Hiroyasu Shimizu

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan

Tomotaro Dote

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan

Kan Usuda

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan

Yumi Toshina

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan

Junko Kato

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan

Akiko Sakai

Department of Chemistry, Osaka Medical College, Takatsuki, Osaka, Japan

Eisuke Furuya

Department of Chemistry, Osaka Medical College, Takatsuki, Osaka, Japan

Koichi Kono

Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan, hyg007{at}art.osaka-med.ac.jp

The effects of glucose infusion on monochloroacetate (MCA) exposure were examined in male rats with a view toward effective clinical treatment for MCA intoxication. Rats were injected with 80 mg/kg sodium monochloroacetate (SMCA) (single lethal dose) and then infused with saline (control group) or 5% or 10% glucose solution at 2 mL/hour for ten hours. No animal in the control group survived the total 14-day follow-up period. The survival rate in 5% glucose group was 57% at ten hours; it decreased to 14% at 14 days. The survival rate in 10% glucose group was 79% at ten hours, and all rats that survived the first ten hours also survived the 14 days. Kaplan -Meier analysis showed the survival rate in 10% glucose group to be improved upon in both the 5% glucose group and the control group. Blood glucose and lactate levels were measured every hour during infusion. Blood glucose levels decreased in the control group but remained in the glucose-infused groups. Although the blood lactate level increased in each group, there was an excellent inverse linear relation between blood glucose levels and blood lactate levels. Thus, continuous parenteral infusion of glucose solution at an early stage after exposure may be an effective clinical therapy for the prevention of hypoglycaemia and metabolic lactic acidosis caused by MCA.

Key Words: exposure • glucose infusion • hypoglycaemia • lactic acidosis • monochloroacetic acid • therapy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Toxicol Ind HealthHome page
J. Kato, T. Dote, H. Shimizu, Y. Shimbo, M. Fujihara, and K. Kono
Lethal acute lung injury and hypoglycemia after subcutaneous administration of monochloroacetic acid
Toxicology and Industrial Health, June 1, 2006; 22(5): 203 - 209.
[Abstract] [PDF]