This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shimizu, K. Articles by Katayama, I. Search for Related Content PubMed PubMed Citation Articles by Shimizu, K. Articles by Katayama, I. Social Bookmarking                         What's this?

Serum antioxidant levels in Yusho victims over 30 years after the accidental poisoning of polychlorinated biphenyls in Nagasaki, Japan

Department of Dermatology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Study Group for the Therapy of ‘Yusho’ at Nagasaki, Japan, kasimizu{at}net.nagasaki-u.ac.jp

Fumihide Ogawa

Department of Dermatology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Study Group for the Therapy of ‘Yusho’ at Nagasaki, Japan

Masahisa Watanabe

Department of Dermatology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Study Group for the Therapy of ‘Yusho’ at Nagasaki, Japan

Takahito Kondo

Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Ichiro Katayama

Department of Dermatology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Study Group for the Therapy of ‘Yusho’ at Nagasaki, Japan

Over 30 years have passed since the accidental polychlorinated biphenyls (PCB) poisoning in Japan and yet high concentrations of PCB are still detected in the serum of the victims. PCB produces superoxide and thus victims of PCB poisoning are in a persistent state of oxidative stress. To examine the antioxidative state, we measured the serum concentrations of Cu, Zn-superoxide dismutase (SOD) and Mn-SOD in 38 victims and 20 age-matched control subjects. The mean serum concentration of Cu, Zn-SOD was significantly lower and that of Mn-SOD higher than those of the control. Such an antioxidative state is indicative of an imbalance of Redox regulation mechanism. Persistence of imbalance could result in serious ailments in the future.

Key Words: polychlorinated biphenyls • superoxide dismutase • Yusho

Toxicology and Industrial Health, Vol. 19, No. 2-6, 37-39 (2003)
DOI: 10.1191/0748233703th173oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. W. Lehmann, J. F. Levine, and J. M. Law Polychlorinated Biphenyl Exposure Causes Gonadal Atrophy and Oxidative Stress in Corbicula fluminea Clams Toxicol Pathol, April 1, 2007; 35(3): 356 - 365. [Abstract] [Full Text] [PDF]