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Toxicology and Industrial Health
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Alteration of the Redox State of Nadph and Glutathione in Perfused Rabbit Lung By Paraquat

Regina Brigelius

Laboratory of Pharmacology National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina

Lori A. Dostal

Laboratory of Pharmacology National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina

Julie K. Horton

Laboratory of Pharmacology National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina

John R. Bend

Laboratory of Pharmacology National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina

The glutathione and NADP + status of perfused rabbit lung was deter mined both before and after perfusion with 1 mM paraquat. The pul monary glutathione redox state was similar to that of liver, having a glutathione/glutathione disulfide ratio of about 240. This ratio was lower in lungs perfused with glucose-free medium, a condition in which NADPH probably becomes limiting. Perfusion with paraquat signifi cantly increased the pulmonary glutathione disulfide content, particu larly in the absence of glucose, resulting in a glutathionelglutathione disulfide ratio of <100. NADP+ levels in rabbit lung were increased approximately two-fold by perfusion with paraquat in medium con taining glucose and three-fold in the absence of glucose.

Toxicology and Industrial Health, Vol. 2, No. 4, 417-428 (1986)
DOI: 10.1177/074823378600200405
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