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Metal mixture inhalation (Cd-Pb) and its effects on the bronchiolar epithelium. An ultrastructural approachFacultad de Medicina, National University of Mexico, Mexico City, Mexico, fortoul{at}servidor.unam.mx
Facultad de Medicina, National University of Mexico, Mexico City, Mexico, FES Iztacala, National University of Mexico, Mexico City, Mexico
Facultad de Química, National University of Mexico, Mexico City, Mexico
Facultad de Medicina, National University of Mexico, Mexico City, Mexico
Facultad de Medicina, National University of Mexico, Mexico City, Mexico
Instituto Nacional de Salud Pública, Cuernavaca, Mexico
Facultad de Química, National University of Mexico, Mexico City, Mexico The current study explores the effects of the inhalation of lead (Pb), Cd and its mixture (Pb-Cd) in a mice model, analysing metal concentrations in the lung, and the morphological modifications in the bronchiolar epithelium identified by scanning electron microscopy after eight weeks of inhalation. Our results indicate that metal concentrations in lung were higher compared to controls; however, Pb concentrations drastically decrease in the mixture. This reduction was also observed in the inhalation chamber. The main changes observed in the bronchiole were mostly in the mixture. The modifications were mainly given by Cd alone and in the mixture, with a decreased number of nonciliated bronchiolar cells and an increased number of bundles of dividing cells. The additive effect of Pb-Cd is suggested, as the extensive damage observed was more evident when mice were exposed to the mixture, and the results endured more research in the area of inhaled mixtures.
Key Words: bronchiole • cadmium • inhalation exposure • lead • metals • mixtures • NCBC • scanning electron microscopy
Toxicology and Industrial Health, Vol. 20, No. 1-5,
69-75 (2004) |
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