Toxicology and Industrial Health

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fortoul, T. I
Right arrow Articles by Saldivar-Osorio, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fortoul, T. I
Right arrow Articles by Saldivar-Osorio, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Toxicology and Industrial Health, Vol. 20, No. 1-5, 69-75 (2004)
DOI: 10.1191/0748233704th196oa

Metal mixture inhalation (Cd-Pb) and its effects on the bronchiolar epithelium. An ultrastructural approach

Teresa I Fortoul

Facultad de Medicina, National University of Mexico, Mexico City, Mexico, fortoul{at}servidor.unam.mx

Maria-Rosa Ávila-Costa

Facultad de Medicina, National University of Mexico, Mexico City, Mexico, FES Iztacala, National University of Mexico, Mexico City, Mexico

Guadalupe Espejel-Maya

Facultad de Química, National University of Mexico, Mexico City, Mexico

Patricia Mussali-Galante

Facultad de Medicina, National University of Mexico, Mexico City, Mexico

Maria del Carmen Ávila-Casado

Facultad de Medicina, National University of Mexico, Mexico City, Mexico

Maria Isidra Hernández-Serrato

Instituto Nacional de Salud Pública, Cuernavaca, Mexico

Liliana Saldivar-Osorio

Facultad de Química, National University of Mexico, Mexico City, Mexico

The current study explores the effects of the inhalation of lead (Pb), Cd and its mixture (Pb-Cd) in a mice model, analysing metal concentrations in the lung, and the morphological modifications in the bronchiolar epithelium identified by scanning electron microscopy after eight weeks of inhalation. Our results indicate that metal concentrations in lung were higher compared to controls; however, Pb concentrations drastically decrease in the mixture. This reduction was also observed in the inhalation chamber. The main changes observed in the bronchiole were mostly in the mixture. The modifications were mainly given by Cd alone and in the mixture, with a decreased number of nonciliated bronchiolar cells and an increased number of bundles of dividing cells. The additive effect of Pb-Cd is suggested, as the extensive damage observed was more evident when mice were exposed to the mixture, and the results endured more research in the area of inhaled mixtures.

Key Words: bronchiole • cadmium • inhalation exposure • lead • metals • mixtures • NCBC • scanning electron microscopy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?