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Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue

Department of General Surgery, Medical Faculty of Inonu University, Malatya, Turkey

Mustafa Iraz

Department of Pharmacology, Medical Faculty of Inonu University, Malatya, Turkey, mustafairaz{at}yahoo.com

Semsettin Sahin

Department of Biochemistry, Medical Faculty of Gaziosmanpasa University, Tokat, Turkey

Atilla Ilhan

Department of Neurology, Medical Faculty of Inonu University, Malatya, Turkey

Nuri Idiz

Ankara University Institute of Forensic Medicine, Ankara, Turkey

Ersin Fadillioglu

Department of Physiology, Medical Faculty of Inonu University, Malatya, Turkey

Rotenone, an insecticide of botanical origin, causes toxicity through inhibition of complex I of the respiratory chain in mitochondria. This study was undertaken to determine whether rotenone-induced liver oxidant injury is prevented by erdosteine, a mucolytic agent showing antioxidant properties. There were four groups of Male Wistar Albino rats: group one was untreated as control; the other groups were treated with erdosteine (50 mg/kg per day, orally), rotenone (2.5 mg/mL once and 1 mL/kg per day for 60 days, i.p.) or rotenone plus erdosteine, respectively. Rotenone treatment without erdosteine increased xanthine oxidase (XO) enzyme activity and also increased lipid peroxidation in liver tissue P < 0.05). The rats treated with rotenone plus erdosteine produced a significant decrease in lipid peroxidation and XO activities in comparison with rotenone group PB ^/ 0.05). Erdosteine treatment with rotenone led to an increase in catalase (CAT) and superoxide dismutase (SOD) activities in comparison with the rotenone group PB ^/ 0.05). There was no significant difference in nitric oxide (NO) level between groups. There were negative correlations between CAT activity and malondialdehyde (MDA) level (r= -0.934, P <0.05) with between CAT and SOD activities (r= -0.714, P <0.05), and a positive correlation between SOD activity and MDA level (r= 0.828, P <0.05) in rotenone group. In the rotenone plus erdosteine group, there was a negative correlation between XO activity and NO level in liver tissue (r= -0.833, P -0.05). In the light of these findings, erdosteine may be a protective agent for rotenone-induced liver oxidative injury in rats.

Key Words: antioxidants • erdosteine • lipid peroxidation • liver • rotenone

Toxicology and Industrial Health, Vol. 20, No. 6-10, 141-147 (2004)
DOI: 10.1191/0748233704th208oa


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