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Comparative toxic potency ranking of chlorophenolsSciences International, Inc., 1800 Diagonal Road, Alexandria, VA 22314, USA
Sciences International, Inc., 1800 Diagonal Road, Alexandria, VA 22314, USA
National Center for Environmental Assessment, US Environmental Protection Agency, Cincinnati, OH 45268, USA, mukerjee.debdas{at}epa.gov Chlorophenols are prevalent in all media of the environment. The most common environmental source of pentachlorophenol (PCP) and other chlorinated phenols are via the lumber industry as a wood preservative and as a pesticide in plant production. The US Environmental Protection Agency’s (EPA) contaminant candidate list (CCL) includes a majority of these compounds as unregulated contaminants. Except for pentachlorophenol, there is a lack of human or animal data base which can be used for human health risk assessment. The specific aim of this study is to develop a rationale to use in vivo nonmammalian, in vitro mammalian and nonmammalian, micro-organism toxicity data base, structural activity, mechanistic and toxicokinetic data bases for developing a relative toxic potency ranking scheme of chlorophenols. Although the toxic potency of chlorophenols was found to increase with the number of chlorines, the potency decreases if the chlorines are attached in the ortho position of the molecules. Based on the LOAELs and mammalian in vitro data, the relative potency of chlorophenols determined to be best estimated by the ratios of log Kow to the 0.55 power. The relationship of the toxic potency derived from such an approach is largely presumptive.
Key Words: chlorophenols • comparative toxicity • risk assessment
Toxicology and Industrial Health, Vol. 21, No. 3-4,
93-111 (2005) |
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