Toxicology and Industrial Health

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mussali-Galante, P
Right arrow Articles by Fortoul, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mussali-Galante, P
Right arrow Articles by Fortoul, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Toxicology and Industrial Health, Vol. 21, No. 5-6, 155-166 (2005)
DOI: 10.1191/0748233705th224oa

DNA damage as an early biomarker of effect in human health

P Mussali-Galante

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

MR Avila-Costa

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México, Facultad de Estudios Superiores Iztacala, UNAM, México City, México

G Piñón-Zarate

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

G Martínez-Levy

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

V Rodríguez-Lara

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

M Rojas-Lemus

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

MC Avila-Casado

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México

TI Fortoul

Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México, fortoul{at}servidor.unam.mx

In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DNA provides a good model to investigate some cellular and molecular mechanisms underlying the basis of genetic toxicology. The nasal epithelium is the first barrier with which environmental pollutants interact, and for this reason this epithelium can be useful as a sentinel in order to assess the interactions between the environment and the living organisms. Taking these phenomena into account and using a simple, sensitive and rapid method such as the single cell gel electrophoresis, we could obtain information and an initial approach on the DNA status. This assay in combination with other techniques that provide more information about other molecular parameters could give us a better view of the biological status of the living cell.

Key Words: antineoplastic drugs • biomarkers • DNA damage • nasal epithelium


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Occup. Environ. Med.Home page
H. Wang, W. Chen, H. Zheng, L. Guo, H. Liang, X. Yang, Y. Bai, J. Sun, Y. Su, Y. Chen, et al.
Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers
Occup. Environ. Med., November 1, 2007; 64(11): 753 - 758.
[Abstract] [Full Text] [PDF]