SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Toxicology and Industrial Health
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mussali-Galante, P.
Right arrow Articles by Fortoul, T. I
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mussali-Galante, P.
Right arrow Articles by Fortoul, T. I
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Inhaled vanadium pentoxide decrease gamma-tubulin of mouse testes at different exposure times

Patricia Mussali-Galante

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Vianey Rodríguez-Lara

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Beatriz Hernández-Tellez

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Maria Rosa Ávila-Costa

Laboratorio de Neuromorfología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México

Laura Colín-Barenque

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Patricia Bizarro-Nevarez

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Gabriela Martínez-Levy

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Marcela Rojas-Lemus

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Gabriela Piñón-Zarate

Liliana Saldivar-Osorio

Facultad de Química, Universidad Nacional Autónoma de México, México D.F

Patricia Diaz-Beck

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Miguel Angel Herrera-Enríquez

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Efraín Tovar-Sánchez

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México

Teresa I Fortoul

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, fortoul{at}servidor.unam.mx

Vanadium is an important environmental and industrial pollutant whose concentrations have increased in the last decades. Due to its status as reproductive toxicant and a microtubule damaging agent, the present study investigated by immunohistochemistry the effect of the inhalation of vanadium pentoxide on gamma-tubulin within somatic and testicular germ cells. Male mice inhaled vanadium pentoxide (V2O5) (0.02 M) 1 h/twice a week for 12 weeks. Our results demonstrated that vanadium accumulates in the testes starting with the initial inhalation (24 h), and this pattern remained until the last week of treatment. In general, vanadium was capable of significantly decreasing the percentage of gamma-tubulin in all analyzed testicular cells (Sertoli, Leydig and germ cells) starting with the first week of treatment. For all cell types studied, regression analysis revealed a negative and significant relationship between the percentage of immunopositive cells to gamma-tubulin and exposure time, showing a time dependent response in all cases. Our findings suggest that alterations on this protein might imply changes in microtubule-involved function such as cell division, which in the testes might lead to damage in the spermatogenesis, leading probably to infertility.

Key Words: cytoskeleton • gamma-tubulin • vanadium • air pollution • seminiferous tubules • reprotoxic agents

Toxicology and Industrial Health, Vol. 21, No. 7-8, 215-222 (2005)
DOI: 10.1191/0748233705th232oa
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




Advertisement