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Fluorosis and its hematological effects

Department of Pediatrics, Suleyman Demirel University Medical School, Isparta, Turkey, erderen{at}yahoo.com

Mustafa Özturk

Department of Public Health, Suleyman Demirel University Medical School, Isparta, Turkey

Ethem Faruk Mumcu

Ankara, Turkey

Duran Canatan

Department of Pediatrics, Pediatric Hematology Division, Suleyman Demirel University Medical School, Isparta, Turkey

Although it has been reported that fluoride ingestion has no influence on various indices of hematopoiesis, some research has been published that excessive fluoride developed anemia and eosinophilia of leukocytes. Isparta is situated on the lake region of Turkey where fluorosis is endemic. Our aim was to explore the hematological effects in rats induced by fluoride. In this study, Wistar-Albino rats were used, divided into two groups as control and fluorized. While the control group was administered commercial water (including 0.07 ppm fluoride), the fluorized group was administered 100 ppm fluoride in commercial drinking water for four months. At the end of four months, hematological indices (Hb, Hct, MCV, MCH, RDW, RBC, WBC, and platelet counts) were measured. In addition, bone marrow samples were investigated. Mean leukocyte counts (WBC) in the control group and fluorized group were 7.07 (2.62-12.25) and 2.76 (3.13-5.24)-/10³/mm³, respectively. We observed displastic changes on granulocytes in the bone marrow samples of the fluorized group. Although there were significant statistical changes in WBC, we did not determine red blood cell and platelet changes in the fluorized group.

Key Words: fluoride • hematopoiesis • leukocyte

Toxicology and Industrial Health, Vol. 21, No. 9, 255-258 (2005)
DOI: 10.1191/0748233705th236oa


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