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Toxicology and Industrial Health
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*ALUMINUM
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Possible peripheral markers for chronic aluminium toxicity in Wistar rats

Amarpreet Kaur

Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Kiran Dip Gill

Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India, kdgill2002{at}yahoo.co.in

This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome oxidase (CO), the terminal enzyme of the electron transport chain, was significantly diminished and that of glucose-6-phosphate dehydrogenase (G-6-PD) was significantly enhanced. Neuromuscular co-ordination was assessed using motor and memory function tests. Deficits were observed suggesting a probable model for chronic Al neurotoxicity.

Key Words: aluminium • brain • cholinesterase • cytochrome oxidase • glucose-6-phosphate dehydrogenase • motor and memory function tests

Toxicology and Industrial Health, Vol. 22, No. 1, 39-46 (2006)
DOI: 10.1191/0748233706th242oa
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