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Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Teresa I Fortoul

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico, fortoul{at}servidor.unam.mx

Maria Rosa Avila-Costa

FES Iztacala, Universidad Nacional Autónoma de México (UNAM) Edo. de Mexico, Mexico

Gabriela Piñón-Zarate

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Vianey Rodriguez-Lara

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Gabriela Martínez-Levy

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Marcela Rojas-Lemus

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Patricia Bizarro-Nevarez

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Patricia Díaz-Bech

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Patricia Mussali-Galante

Departamento Biología Celular y Tisular, Facultad de Medicina, UNAM CP 04510, Mexico City, Mexico

Laura Colin-Barenque

FES Iztacala, Universidad Nacional Autónoma de México (UNAM) Edo. de Mexico, Mexico

Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V₂O₅ 0.02 M 1 h twice weekly over 12 weeks. Blood samples were obtained by direct heart puncture; Wright stained smears were used for platelet quantification. An increase in platelet count from the third week of exposure was observed, as well as the presence of megaplatelets. Our results demonstrate, for the first time, that V induces thrombocytosis and it might correlate with some thromboembolic diseases. Further analysis is needed to evaluate the functionality of these platelets as well as the cause of its increase.

Key Words: inhalation exposure • megaplatelets • metals • thrombocytosis • vanadium References

Toxicology and Industrial Health, Vol. 22, No. 3, 113-116 (2006)
DOI: 10.1191/0748233706th250oa


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