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Toxicology and Industrial Health
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Influence of thyroxine and n-propylthiouracil on nephro-toxicity of inorganic arsenic in rat

SVS Rana

Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut-250004, India, sureshvs_rana{at}yahoo.com

Tanu Allen

Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut-250004, India

The effect of hyper or hypoactive thyroid on the renal toxicity of arsenic trioxide has been studied in rats. It was observed that pre-treatment of rats with thyroxine stimulates arsenic excretion in urine. The anti-thyroid drug n-propylthiouracil (PTU), inhibits the accumulation of arsenic in renal tissue. Both treatments affect the renal pathology. Histopathological lesions are less severe in PTU and arsenic-treated rats in comparison to thyroxine and arsenic-treated rats. Ultrastructural studies support light microscopical observations. An adaptive response was noticed against arsenic in PTU pre-treated rats. We attribute this response to decreased glutathione-S-transferase (GSH) activity and increased GSH synthesis in the kidney. A relationship between thyroidal activity and arsenic toxicity is suggested by present observations.

Key Words: GSH • kidney • n-propylthiouracil • arsenic • l-thyroxine

Toxicology and Industrial Health, Vol. 22, No. 3, 137-145 (2006)
DOI: 10.1191/0748233706th251oa
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