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Toxicology and Industrial Health, Vol. 22, No. 4, 173-179 (2006)
DOI: 10.1191/0748233706th254oa

The protective effect of hydrated sodium calcium aluminosilicate against the adverse effects of Aflatoxin B1 on D. melanogaster

Turgay Sisman

Department of Biology, Science and Art Faculty, Atatürk University, 25240 Erzurum, Turkey, turgaysisman{at}gmail.com.tr

The main aim of this study was to investigate the effects of Aflatoxin B1 (AFB1) and Aflatoxin B1-hydrated sodium calcium aluminosilicate (HSCAS) on various developmental stages of Drosophila melanogaster. Different concentrations of AFB1 and HSCAS-AFB1 were administered during the developmental periods of the fly (egg, larvae and pupae). When the F1 progeny of control and application groups were compared, AFB1 was found to extend the process of metamorphosis and decrease the total number of offspring. However, these negative effects were inhibited with HSCAS treatment at different concentrations (5.0 and 10.0 ppm). These results suggest that HSCAS could effectively inhibit AFB1-induced abnormalities in the developmental stages of D. melanogaster.

Key Words: adsorbent • AFB1 • developmental stages • Drosophila melanogaster • HSCAS • protective effects


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H. Turkez and T. Sisman
Anti-genotoxic effect of hydrated sodium calcium aluminosilicate on genotoxicity to human lymphocytes induced by aflatoxin B1
Toxicology and Industrial Health, March 1, 2007; 23(2): 83 - 89.
[Abstract] [PDF]