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Toxicology and Industrial Health, Vol. 22, No. 8, 321-327 (2006)
DOI: 10.1177/0748233706071765

Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids

Ming W Chou

National Center for Toxicological Research, Jefferson, AR 72079, USA, mchou{at}nctr.fda.gov

Peter P Fu

National Center for Toxicological Research, Jefferson, AR 72079, USA

We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)- derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report that DHP-derived DNA adducts are formed in the liver of female F344 rats, gavaged with three dietary supplements (comfrey root extract, comfrey compound oil, and coltsfoot root extract), or an extract of a Chinese herbal plant, flos farfara (Kuan Tong Hua).

Key Words: dietary supplement • DNA adduct • pyrrolizidine alkaloid • riddelliine


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