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Toxicology and Industrial Health, Vol. 23, No. 1, 55-59 (2007)
DOI: 10.1177/0748233707077436
© 2007 SAGE Publications

Risk assessment of occupational exposure to polycyclic aromatic hydrocarbons by means of urinary1-hydroxypyrene

Giovanni Maina

Department of Traumathology, Orthopaedic and Occupational Medicine, University of Torino, Torino, Italy, giovanni.maina{at}unito.it

Marco Manzari

Department of Traumathology, Orthopaedic and Occupational Medicine, University of Torino, Torino, Italy

Antonio Palmas

Department of Traumathology, Orthopaedic and Occupational Medicine, University of Torino, Torino, Italy

Valter Passini

Department of Traumathology, Orthopaedic and Occupational Medicine, University of Torino, Torino, Italy

Francesca Larese Filon

Institute of Occupational Health, University of Trieste, Trieste, Italy

Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydrocarbons was carried out on fifty-two workers exposed to diesel exhaust. Urinary 1-hydroxypyrene was employed as a biomarker of internal dose. Significant urinary 1-hydroxypyrene differences between smokers and non-smokers were found. Twenty per cent of urinary 1-hydroxypyrene values exceeded benchmark level for genotoxic effect, while the results of environmental monitoring excluded the existence of exposure to polycyclic aromatic hydrocarbons. In the absence of greater knowledge about the relationship between urinary 1-hydroxypyrene and genotoxic effects under the conditions of very low exposure, extreme caution is recommended when this biomarker of internal dose is employed as an indicator of genotoxic risk. Toxicology and Industrial Health 2007; 23: 55—59.

Key Words: diesel exaust • genotoxic risk • polycyclic aromatic hydrocarbons • smoking • urinary 1-hydroxypyrene


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