This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Harris, D. T. Articles by Witten, M. Search for Related Content PubMed PubMed Citation Articles by Harris, D. T. Articles by Witten, M. Social Bookmarking                         What's this?

JP-8 jet fuel exposure rapidly induces high levels of IL-10 and PGE2 secretion and is correlated with loss of immune function

Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA, davidh{at}u.arizona.edu

Debbie Sakiestewa

Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA

Dominic Titone

Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA

Mark Witten

Department of Pediatrics, University of Arizona, Tucson AZ 85724, USA

The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has demonstrated that JP-8 exposure is immunosuppressive. In the present study, the potential mechanisms for the effects of JP-8 exposure on the immune system were investigated. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion of two immunosuppressive agents; namely, interleukin-10 (IL-10) and prostaglandin E2 (PGE2). JP-8 exposure rapidly induced a persistently high level of serum IL-10 and PGE2 at an exposure concentration of 1000 mg/m³. IL-10 levels peaked at 2h post-JP-8 exposure and then stabilized at significantly elevated serum levels, while PGE2 levels peaked after 2—3 days of exposure and then stabilized. Elevated IL-10 and PGE2 levels may at least partially explain the effects of JP-8 exposure on immune function. Elevated IL-10 and PGE2 levels, however, cannot explain all of the effects due to JP-8 exposure (e.g., decreased organ weights and decreased viable immune cells), as treatment with a PGE2 inhibitor did not completely reverse the immunosuppressive effects of jet fuel exposure. Thus, low concentration JP-8 jet fuel exposures have significant effects on the immune system, which can be partially explained by the secretion of immunosuppressive modulators, which are cumulative over time.

Key Words: hydrocarbon inhalation • IL-10 • immunotoxicology • jet fuel • JP-8 • PGE2

Toxicology and Industrial Health, Vol. 23, No. 4, 223-230 (2007)
DOI: 10.1177/0748233707083956


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. Ramos, A. Y. Limon-Flores, and S. E. Ullrich JP-8 Induces Immune Suppression via a Reactive Oxygen Species NF-{kappa}{beta}-Dependent Mechanism Toxicol. Sci., March 1, 2009; 108(1): 100 - 109. [Abstract] [Full Text] [PDF]

				D. Harris, D Sakiestewa, D Titone, X He, J Hyde, and M Witten JP-8 jet fuel exposure potentiates tumor development in two experimental model systems Toxicology and Industrial Health, November 1, 2007; 23(10): 617 - 623. [Abstract] [PDF]

				D. Harris, D Sakiestewa, X He, D Titone, and M Witten Effects of in utero JP-8 jet fuel exposure on the immune systems of pregnant and newborn mice Toxicology and Industrial Health, October 1, 2007; 23(9): 545 - 552. [Abstract] [PDF]