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Toxicology and Industrial Health, Vol. 23, No. 7, 403-410 (2007)
DOI: 10.1177/0748233707077431

Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury

Zhaofa Xu

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China, zfxu{at}mail.cmu.edu.cn

Jinghua Yang

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China

Jiaming Yu

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China

Zhongwei Yin

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China

Wei Sun

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China

Jing Li

Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China

Objective: To study the effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury. Methods: The rats in groups 1, 2 and 3 were sc injected with 0.75, 1.5 and 2.5mg/kg HgCl2, respectively. Fourth group rats were ip injected with 0.5mmol/kg BSO and 4h later sc administrated with 0.75mg/kg HgCl2. The rats in groups 5, 6 and 7 were ip injected with 3 mmol/kg GSH, 4mmol/kg Vit-C, 200 µmol/kg DMPS, respectively, and 2h later sc administrated with 2.5mg/kg HgCl2. Eighth group rats were sc injected with saline as a control. Mercury concentrations in the liver, renal cortex and urine, urinary NAG, ALP, LDH activities, protein and BUN contents were determined. Results: Urinary NAG, ALP activities, protein and BUN contents in the rats of BSO pretreatment group were significantly higher than that of 0.75 mg/kg HgCl2 alone group and control group. As compared with 2.5 mg/kg HgCl2 alone group, urinary NAG, ALP, LDH activities, urinary protein and BUN contents decreased significantly. Conclusion: BSO pretreatment could enhance the renal toxicity of mercury and GSH, Vit-C and DMPS pretreatment had antagonistic effects on nephrotoxicity of mercury. Toxicology and Industrial 2007; 23: 403—410.

Key Words: mercury • nephrotoxicity • buthionine sulfoximine • gluthionein • vitamin C • sodium 2,3-dimercato-1-propanesulfonate


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