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Toxicology and Industrial Health
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research-article

Effects of formaldehyde and xylene on CD4- and CD8-positive T cells in bronchus-associated lymphoid tissue in rats

M Sandikci

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

U Eren

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

S Kum

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

The aim of this study was to determine the localization and number of CD4- and CD8-positive T lymphocytes in bronchus-associated lymphoid tissue (BALT) of the embryos and newborns or young and adult rats exposed to formaldehyde (6 ppm), technical xylene (300 ppm), or a combination of these two agents (3 ppm + 150 ppm) for 6 weeks (8 h/day). A total of 96 female Sprague-Dawley rats were used. The CD4-positive cells were localized predominately in area under the epithelium and in the periphery of BALT follicles after the exposure period. However, CD8-positive cells were localized mainly in the periphery of BALT follicles after the exposure period. The number of CD4- and CD8-positive lymphocytes significantly increased in exposed young and adult rats compared to the respective controls. These results suggest that formaldehyde and/or xylene may affect the local immunity in BALT particularly in young and adult rats.

Key Words: BALT • formaldehyde • T cell • xylene

Toxicology and Industrial Health, Vol. 23, No. 8, 471-477 (2007)
DOI: 10.1177/0748233708089025


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This article has been cited by other articles:


Home page
Toxicol Ind HealthHome page
M. Sandikci, K. Seyrek, H. Aksit, and H. Kose
Inhalation of formaldehyde and xylene induces apoptotic cell death in the lung tissue
Toxicology and Industrial Health, August 1, 2009; 25(7): 455 - 461.
[Abstract] [PDF]



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