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Toxicology and Industrial Health, Vol. 23, No. 8, 471-477 (2007)
DOI: 10.1177/0748233708089025

research-article

Effects of formaldehyde and xylene on CD4- and CD8-positive T cells in bronchus-associated lymphoid tissue in rats

M Sandikci

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

U Eren

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

S Kum

Faculty of Veterinary Medicine, Department of Histology and Embryology, Adnan Menderes University, Aydin, Turkey

The aim of this study was to determine the localization and number of CD4- and CD8-positive T lymphocytes in bronchus-associated lymphoid tissue (BALT) of the embryos and newborns or young and adult rats exposed to formaldehyde (6 ppm), technical xylene (300 ppm), or a combination of these two agents (3 ppm + 150 ppm) for 6 weeks (8 h/day). A total of 96 female Sprague-Dawley rats were used. The CD4-positive cells were localized predominately in area under the epithelium and in the periphery of BALT follicles after the exposure period. However, CD8-positive cells were localized mainly in the periphery of BALT follicles after the exposure period. The number of CD4- and CD8-positive lymphocytes significantly increased in exposed young and adult rats compared to the respective controls. These results suggest that formaldehyde and/or xylene may affect the local immunity in BALT particularly in young and adult rats.

Key Words: BALT • formaldehyde • T cell • xylene


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