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Toxicology and Industrial Health
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research-article

Thioglycolic acid inhibits mouse oocyte maturation and affects chromosomal arrangement and spindle configuration

SY Hou

Department of Nutrition and Food Hygiene, Harbin Medical University, Heilongjiang, China

L Zhang

Department of Nutrition and Food Hygiene, Harbin Medical University, Heilongjiang, China

K Wu

Department of Nutrition and Food Hygiene, Harbin Medical University, Heilongjiang, China

L Xia

The First Hospital of Harbin Medical University, Harbin, Heilongjiang, China

Previous studies have shown that thioglycolic acid (TGA) leads to potential reproductive toxicology. To clarify the exact effects of this compound on reproduction, mice oocytes were treated with different TGA doses. At the end of the culture period, the nuclear status of mice oocytes was assessed under an inverted microscope. After immunofluorescence staining, the chromosomal arrangement and spindle configuration of oocytes were evaluated. The results indicated that TGA decreases the percentage of first polar body formation but does not influence that of germinal vesicle breakdown. TGA induces abnormal chromosomal arrangement and spindle elongation. In conclusion, TGA inhibits in-vitro maturation of mice oocytes and affects chromosomal arrangement and spindle configuration. Furthermore, it probably interferes with biochemical changes that occur during meiosis, resulting in aberrant development.

Key Words: chromosome • in-vitro maturation • oocytes • spindle • thioglycolic acid

Toxicology and Industrial Health, Vol. 24, No. 4, 227-234 (2008)
DOI: 10.1177/0748233708095862
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