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Toxicology and Industrial Health
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research-article

ATSDR evaluation of health effects of benzene and relevance to public health

S Wilbur

Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia, USA sdw9{at}cdc.gov

D Wohlers

Syracuse Research Corporation, Syracuse, New York, USA

S Paikoff

Syracuse Research Corporation, Syracuse, New York, USA

LS Keith

Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia, USA

O Faroon

Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia, USA

As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Benzene. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of benzene. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health.

Key Words: benzene • health effects • levels of significant exposure • minimal risk levels • toxicokinetics • toxicological profile

Toxicology and Industrial Health, Vol. 24, No. 5-6, 263-398 (2008)
DOI: 10.1177/0748233708090910
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