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Toxicology and Industrial Health
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Histopathological changes in the liver and kidney tissues of Wistar albino rat exposed to fenitrothion

S Afshar

Department of Biology, Faculty of Science, Urmia University, Urmia, Iran afshar_biology{at}yahoo.com

AA Farshid

Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

R Heidari

Department of Biology, Faculty of Science, Urmia University, Urmia, Iran

M Ilkhanipour

Department of Biology, Faculty of Science, Urmia University, Urmia, Iran

The aim of this study was to investigate the dose-related effects of fenitrothion (FNT) on the liver and kidney. The study was conducted on 8-week-old male Wistar rats that were divided into four groups (three experimental groups and one control group) and were treated orally with different doses (25, 50, 100 mg/kg) of FNT for 28 consecutive days. After treatment, the rats were anesthetized with ether and liver and kidney samples were taken for histological studies. The results showed that the histopathological changes in the liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leukocytic infiltration in the portal area, severe congestion, and hemorrhage. These changes were dose dependent. Marked tubular dilation, hydropic degeneration in tubular epithelium, moderate congestion, and hemorrhage in the cortical and medulla part of the kidney were recorded. Histopathologic examination of the liver and kidney indicated a significant injury only in rats receiving 100 mg/kg FNT.

Key Words: fenitrothion • histopathology • kidney • liver

Toxicology and Industrial Health, Vol. 24, No. 9, 581-586 (2008)
DOI: 10.1177/0748233708100090
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