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Urinary level of nickel and acute leukaemia in Chinese children

Shanghai XinHua Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China

XM Jin

Shanghai Children Medical Center of Shanghai Jiao Tong University School of Medicine, Shanghai, China

CH Yan

Shanghai XinHua Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China

Y Tian

Shanghai XinHua Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China; Department of Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China

JY Tang

Shanghai Children Medical Center of Shanghai Jiao Tong University School of Medicine, Shanghai, China

XM Shen

Shanghai XinHua Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China xminshen{at}gmail.com

The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage but might also be a risk factor for many diseases including cancer. Metal exposure may play an important role in oxidative DNA damage among children. However, few studies on urinary 8-OHdG and metals have been conducted in children with acute leukemia. In the present study, urinary Ni and 8-OHdG were examined in 116 children with acute leukaemia (94 acute lymphoid leukaemia [ALL] and 22 acute myeloid leukaemia [AML]) and 51 healthy child controls. Our result showed that urinary Ni in acute leukaemia patients (ALL: 68.40 ± 133.98, AML: 41.48 ± 76.31 ng/mg creatinine) was significantly higher than that in controls (62.47 ± 124.90 vs 17.63 ± 46.17 ng/mg creatinine, P < 0.05). Similarly, the pretherapy level of urinary 8-OHdG in patients (ALL: 11.83 ± 16.23, AML: 12.36 ± 11.36 ng/mg creatinine) was significantly elevated compared with controls (11.92 ± 15.42 vs 4.03 ± 4.70 ng/mg creatinine, P < 0.05). Moreover, urinary 8-OHdG and urinary Ni showed a weak but significant association with increased risk of childhood leukaemia. The present study suggests that Ni may be an etiologic factor for childhood acute leukaemia by oxidative DNA damage.

Key Words: 8-hydroxy-2'-deoxyguanosine • biomarker • heavy metals • leukaemia • nickel

Toxicology and Industrial Health, Vol. 24, No. 9, 603-610 (2008)
DOI: 10.1177/0748233708100091


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