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Toxicology and Industrial Health
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research-article

The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes

L Alpsoy

Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey lalpsoy{at}fatih.edu.tr

A Yildirim

Atatürk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey

G Agar

Atatürk University, Faculty of Art and Science, Department of Biology, Erzurum, Turkey

The aim of this study was to investigate the possible protective role of vitamin A, C, and E on aflatoxin B1-induced in human lymphocytes using biochemical approaches. The control group received dimethyl sulfoxide, the second group of cultures were administered aflatoxin B1 (AFB1) at a dose of 5 µM. The other group of cultures were treated with AFB1+vitamin A (0.5 and 1.0 and 1.5 µM) and AFB1+vitamin C (25, 50, and 100 µM) and AFB1+vitamin E (40, 100, and 200 µM). The results of this experiment show that AFB1 significantly decreased the level of GSH and the activities of superoxide dismutase and GPx and increased level of malondialdehyde. Simultaneous supplementation with vitamin A, C, and E restored these parameters to that of normal range. In conclusion, vitamin A, C, and E exhibited protective effects in human lymphocytes by inhibiting AFB1-induced ROS generation.

Key Words: aflatoxin B1 • antioxidant enzymes • genotoxicity • vitamin A, C and E

Toxicology and Industrial Health, Vol. 25, No. 2, 121-127 (2009)
DOI: 10.1177/0748233709103413
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