This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pavlou, P Articles by Grando, S. Search for Related Content PubMed PubMed Citation Articles by Pavlou, P Articles by Grando, S. Social Bookmarking                         What's this?

In-vivo data on the influence of tobacco smoke and UV light on murine skin

Laboratory of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

M Rallis

Laboratory of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece rallis{at}pharm.uoa.gr

G Deliconstantinos

Laboratory of Experimental Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

G Papaioannou

Laboratory of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

SA Grando

Laboratory of Dermatological Research, School of Medicine, University of California – Irvine, Irvine, USA

Inhaled tobacco smoke comes in direct contact with few organs such as mouth, lungs, and stomach. Cigarette smoke (CS) in lungs has been extensively studied. However, limited data exist on its effect on skin, and there are no long-term experimental studies suggesting toxic effects on skin. Even though it is generally accepted that CS is among the main factors of skin aging, the number of experimental studies showing this aging effect is limited. We hereby studied the effect of long-term exposure to CS on the skin of hairless mice in combination with or without ultraviolet (UV) light. In addition, we investigated potential skin protection by a potent antioxidant namely procyanidine-rich French maritime pine bark extract (PBE) pycnogenol. Male and female hairless SKH-2 mice were exposed for 10 months to tobacco smoke and/or UV light in vivo, and their effects on skin were investigated. Some biophysical parameters such as development of erythema, transepidermal water loss (TEWL), and skin elasticity were measured. The results show that UV and CS may be acting synergistically, as shown by the enhanced TEWL, erythema values, epitheliomas, and squamous cell carcinomas (SCCs) observed, whereas PBE seems to protect skin against SCC.

Key Words: hairless mice • long-term exposure • pycnogenol • skin • synergism • tobacco smoke • toxic effects • ultraviolet light

Toxicology and Industrial Health, Vol. 25, No. 4-5, 231-239 (2009)
DOI: 10.1177/0748233709103209


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?