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Toxicology and Industrial Health
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research-article

Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes

C Aldinucci

Department of Physiology, University of Siena, 53100 Siena, Italy

A Carretta

Department of Physiology, University of Siena, 53100 Siena, Italy

SM Maiorca

Department of Physiology, University of Siena, 53100 Siena, Italy

S Leoncini

Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy

C Signorini

Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy

L Ciccoli

Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy

GP Pessina

Department of Physiology, University of Siena, 53100 Siena, Italy pessina{at}unisi.it

Nerve cells are very responsive to weak pulsed electromagnetic fields (EMFs). Such non-ionizing radiation, with frequencies of 0–300 Hz and 0.1–100 mT, can affect several cellular activities, with unusual dose–response characteristics. The present study examined the effect of a 2-h exposure of synaptosomes on a system generating a peak magnetic field of 2 mT. We evaluated the changes of the synaptosomal mitochondrial respiration rate and ATP production, membrane potential, intrasynaptosomal Ca2+ concentration, and the release of free iron and F2-isoprostanes. O2 consumption and ATP production remained unchanged in exposed synaptosomes. The intrasynaptosomal Ca2+ concentration decreased slowly and no depolarization of the synaptosomal membrane was detected. Finally, the release of free iron and F2-isoprostanes by synaptosomal suspensions also remained unchanged after EMF exposure. These results indicate that the physiological behavior of cortical synaptosomes was unaffected by weak pulsed EMFs.

Key Words: electromagnetic field • F2-isoprostanes • free iron release • free radicals • synaptosomes • membrane potential

Toxicology and Industrial Health, Vol. 25, No. 4-5, 249-252 (2009)
DOI: 10.1177/0748233709103031
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