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Toxicology and Industrial Health
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research-article

Antioxidant effect of polyphenolic glabridin on LDL oxidation

E Carmeli

Physical Therapy, Tel Aviv University, Tel Aviv, Israel elie{at}post.tau.ac.il

Y Fogelman

Physical Therapy, Tel Aviv University, Tel Aviv, Israel

This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects’ oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.

Key Words: antiatherosclerotic affects • cardiovascular diseases • glabridin • LDL oxidation • licorice plant • Sienna conference

Toxicology and Industrial Health, Vol. 25, No. 4-5, 321-324 (2009)
DOI: 10.1177/0748233709103034
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