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Toxicology and Industrial Health
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research-article

Whey proteins influence hepatic glutathione after CCl4 intoxication

E Balbis

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

S Patriarca

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

AL Furfaro

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

S Millanta

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

SG Sukkar

Dietetics and Nutritional Unit, San Martino University-Hospital, Genova. Italy

UM Marinari

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

MA Pronzato

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

D Cottalasso

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy

N Traverso

Department of Experimental Medicine, Section of General Pathology, University of Genova, Genova, Italy ntravers{at}medicina.unige.it

Whey proteins (WP) are known to contain more cysteine than casein (CAS), so it is suggested that they should ameliorate the oxidative equilibrium in the organisms. To evaluate the influence of a WP-based diet on liver glutathione (GSH) content, male Sprague-Dawley rats were fed for 3 weeks a balanced liquid diet containing either WP or CAS as main source of protein. Liver GSH content was evaluated at the end of the treatment by high performance liquid chromatography (HPLC), both in basal conditions and after oxidative stress induced by CCl4 acute intoxication. In basal conditions, WP diet significantly increased hepatic GSH in comparison to CAS diet. After CCl4 intoxication, hepatic GSH was negligibly increased in CAS group, while its increase was much more marked in WP group, so that the difference between the two diets was significant; this suggests that WP provided rats with better ability to increase their GSH synthesis in case of need.

Key Words: antioxidant defense • carbon tetrachloride • glutathione • oxidative stress • whey protein

Toxicology and Industrial Health, Vol. 25, No. 4-5, 325-328 (2009)
DOI: 10.1177/0748233709104870
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