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Lipoperoxidation and antioxidant capacity in patients with poorly controlled type 2 diabetes

Department of Pharmacology, University of Florence, Florence, Italy maura.lodovici{at}unifi.it

E Bigagli

Department of Pharmacology, University of Florence, Florence, Italy

G Bardini

Department of Clinical Physiopathology, Unit of Endocrinology, University of Florence, Florence, Italy

CM Rotella

Department of Clinical Physiopathology, Unit of Endocrinology, University of Florence, Florence, Italy

Type 2 diabetes is a heterogeneous disease resulting from insulin resistance and/or from a β-cell secretory defect. Hyperglycemia, which occurs during type 2 diabetes, causes disorders of oxidative–antioxidative balance in the cells, leading to increased free-radical formation. Reduced antioxidant capacity is supposed to be one of the causes of the occurrence of complications in type 2 diabetes. The aim of this study was to evaluate lipoperoxidation and plasma antioxidant status in patients with poorly controlled type 2 diabetes with or without complications. In this study, 15 patients with type 2 diabetes without complications and 11 patients with type 2 diabetes with complications were enrolled. The ‘ferric-reducing ability of plasma’ showed no differences between the two experimental groups. A small, nonsignificant, Superoxide dismutase (SOD) activity reduction was observed in patients with diabetes with complications when compared to those patients with diabetes without complications; on the contrary, we found increased lipoperoxidation in patients with diabetes with complications compared with those patients with diabetes without complications. We also observed a positive correlation between malondialdehyde levels and high density lipoprotein or vitamin E in all analyzed patients with type 2 diabetes. Data obtained from our study show that patients with poorly controlled type 2 diabetes with complications have higher lipoperoxidation than patients with complication-free diabetes, although a residual compensatory response to hyperglycemia-induced oxidative stress occurs.

Key Words: diabetes • HDL • lipoperoxidation • malondialdehyde • SOD activity • vitamin E

Toxicology and Industrial Health, Vol. 25, No. 4-5, 337-341 (2009)
DOI: 10.1177/0748233709106464


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