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Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats

Department of Anatomy, Rize University School of Medicine, Rize, Turkey

E Odaci

Department of Histology and Embryology, Karadeniz Technical University School of Medicine, Trabzon, Turkey eodaci{at}gmail.com

H Mollaoglu

Department of Physiology, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey

K Ucok

Department of Physiology, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey

S Kaplan

Department of Histology and Embryology, Ondokuz Mayis University School of Medicine, Samsun, Turkey

Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their roles in the development of the pyramidal cells of the cornu ammonis in postnatal life. Two groups of pregnant rats, a control group and an experimental group, that were exposed to an electromagnetic field were used. For obtaining electromagnetic field offspring, the pregnant rats were exposed to 900 megahertz electromagnetic fields during the 1–19th gestation days. There were no actions performed on the control group during the same period. The offspring rats were spontaneously delivered—control group (n = 6) and electromagnetic field group (n = 6). Offspring were sacrificed for stereological analyses at the end of the 4th week. Pyramidal cell number in rat cornu ammonis was estimated using the optical fractionator technique. It was found that 900 megahertz of electromagnetic field significantly reduced the total pyramidal cell number in the cornu ammonis of the electromagnetic field group (P < 0.001). Therefore, although its exact mechanism is not clear, it is suggested that pyramidal cell loss in the cornu ammonis could be due to the 900 megahertz electromagnetic field exposure in the prenatal period.

Key Words: cornu ammonis • electromagnetic field • pyramidal cell • rat • stereology

Toxicology and Industrial Health, Vol. 25, No. 6, 377-384 (2009)
DOI: 10.1177/0748233709106442


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