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Toxicology and Industrial Health
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Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: In vitro studies

Sameeh A Mansour

Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department, National Research Centre (NRC), Dokki, Cairo, Egypt, samansour{at}hotmail.com

Abdel-Tawab H Mossa

Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department, National Research Centre (NRC), Dokki, Cairo, Egypt

Tarek M Heikal

Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department, National Research Centre (NRC), Dokki, Cairo, Egypt

Erythrocytes are a convenient model to understand the membrane oxidative damage induced by various xenobiotic pro-oxidants. This study was designed to investigate the possibility of methomyl (Lannate® 90% SP), S-methyl N-(methylcarbamoyloxy) thioacetimidate, to induce oxidative stress response in rat erythrocytes in vitro. Erythrocytes were incubated for 4 hours at 37°C with different concentrations (0.0, 0.1, 0.5, 1.0, 1.5 and 2.0 mM) of methomyl. The results showed that methomyl decreased acetylcholinesterase (AChE), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities and increased level of lipid peroxidation (LPO) as well as the percentage of haemolysis. The response occurred in a concentration-dependent manner. The study suggested that methomyl has the capability to induce oxidative damage as evidenced by increasing LPO and perturbations in various antioxidant enzymes.

Key Words: antioxidant enzymes • erythrocytes • in vitro • lipid peroxidation • Methomyl

Toxicology and Industrial Health, Vol. 25, No. 8, 557-563 (2009)
DOI: 10.1177/0748233709349829
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