This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pitha, J. V. Articles by Silva, F. G. Search for Related Content PubMed Articles by Pitha, J. V. Articles by Silva, F. G. Social Bookmarking                         What's this?

Occupational Hydrocarbon Exposure and Renal Histopathology

Department of Pathology Veterans Administration Medical Center Oklahoma City, Oklahoma

George P. Hemstreet

Departments of Urology, Pathology, Microbiology & Immunology and Environmental Health University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma

Nabih R. Asal

Department of Biostatistics & Epidemiology University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma

Robert L. Petrone

Urology Section Veterans Administration Medical Center Oklahoma City, Oklahoma

Benjamin F. Trump

Department of Pathology University of Maryland School of Medicine Baltimore, Maryland

Fred G. Silva

Department of Pathology Southwest Medical School Dallas, Texas

A blinded, retrospective study of histological sections from ten hydrocarbon-exposed and twenty unexposed nephrectomized renal cell carcinoma cases was conducted to evaluate the histopathologic features present in the apparently normal kidney parenchyma removed with the tumor. Tissue sections from each of the thirty cases were independently reviewed by three consulting pathologists and scored using well defined criteria. Occupational hydrocarbon exposure indices were developed by a team of industrial hygienists and applied to the detailed occupational history of each exposed case. A positive correlation was observed between age and the total renal pathology score (r_s = .40, p < .03). No correlation was found between indices of occupational hydrocarbon exposure and renal pathology scores among exposed cases. No significant differences in renal pathology scores were noted when exposed cases were matched to unexposed cases by age, sex, and race. These results are limited by the inclusion of only cases with historical hydrocarbon exposures. It is recommended that a follow-up study be conducted, utilizing sensitive quantitative methods, to define what, if any, cytopathologic renal effects occur in conjunction with current occupational exposures to hydrocarbons.

Key Words: histopathology • hydrocarbons • occupational exposure • renal.

Toxicology and Industrial Health, Vol. 3, No. 4, 491-506 (1987)
DOI: 10.1177/074823378700300404


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?