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Toxicology and Industrial Health
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Influence of Glibenclamide On the Efficacy of Calcium Trisodium Pentetat as an Antidote for Cadmium Toxicity

Prakash C. Tewari

Industrial Toxicology Research Centre Lucknow, India

Sushil K. Tandon

Industrial Toxicology Research Centre Lucknow, India

Cadmium causes hyperglycemia, activation of hepatic and renal gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase, increases hepatic and renal zinc, renal copper and decreases hepatic and renal iron levels in rats. Glibenclamide, a hypoglycemic agent, significantly reversed most of the Cd effects, enhanced fecal excretion of Cd and potentiated urinary and fecal elimination of Cd by calcium trisodium diethylenetriaminepentaacetate (CaNa3DTPA), a commonly used metal chelator. However, the restoration of Cd-induced alterations in carbohydrate metabolism was not related to elimination of Cd from the tissues.

Key Words: cadmium • calcium trisodium pentetat • enzymes • glibenclamide • rat • toxicity.

Toxicology and Industrial Health, Vol. 4, No. 1, 39-47 (1988)
DOI: 10.1177/074823378800400104
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