SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Toxicology and Industrial Health
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mehlman, M.A.
Right arrow Articles by Legator, M.S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mehlman, M.A.
Right arrow Articles by Legator, M.S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Dangerous and Cancer-Causing Properties of Products and Chemicals in the Oil Refining and Petrochemical Industry - Part II: Carcinogenicity, Mutagenicity, and Developmental Toxicity of 1,3-Butadiene

M.A. Mehlman

UMDNJ-Robert Wood Johnson Medical School Department of Environmental and Community Medicine 675 Hoes Lane, Piscataway, New Jersey 08854

M.S. Legator

Division of Environmental Toxicology University of Texas Medical Branch Galveston, Texas 77550

1,3-butadiene (BD) is present in synthetic rubber and motor fuels (gasoline). BD is shown to cause lymphocytic lymphomas, heart hemangiosarcomas, lung alveolar bronchiolar cancers, forestomach-squamous cell cancers, harderian gland neoplasms, preputial gland adenoma or carcinoma, liver-hepatocellular cancers, mammary gland acinar cell carcinomas, ovary-glanulosa cell carcinoma, brain cancers, pancreas adenoma and carcinoma, testis-Leydig cell tumors, thyroid follicular adenoma and carcinoma, and zymbal gland carcinoma in rodents and to date no exposure level has been established at which this chemical does not cause cancers.

In humans BD causes increase in lymphomas, leukemias, and other cancers of hematopoietic systems and organs. BD is also a potent alkylating agent, directly toxic to developing embryos and damages progeny after parental exposure.

Toxicology and Industrial Health, Vol. 7, No. 3, 207-222 (1991)
DOI: 10.1177/074823379100700306
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol Ind HealthHome page
M. A. Mehlman
Dangerous and Cancer-Causing Properties of Products and Chemicals in the Oil-Refining and Petrochemical Industry--Part Xxii: Health Hazards From Exposure To Gasoline Containing Methyl Tertiary Butyl Ether: Study of New Jersey Residents
Toxicology and Industrial Health, September 1, 1996; 12(5): 613 - 627.
[Abstract] [PDF]


Advertisement