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Concentration and age-dependent elimination kinetics of polychlorinated dibenzofurans in Yucheng and Yusho patients

Private Consultant, Philadelphia, Pennsylvania, USA

BD Kerger

Health Science Resource Integration, Tallahassee, Florida, USA

DJ Paustenbach

ChemRisk, Inc., San Francisco, California, USA

JJ Ryan

Health Canada, Ottawa, Ontario, Canada

Y Masuda

Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan

Half-life estimates of three polychlorodibenzofurans (PCDFs) were calculated using serial blood samples collected over a 15 to 19-year period. Blood fat PCDFs were modeled in eight individuals who were exposed to contaminated rice oil in Japan (Yusho, n = 5) and in Taiwan (Yucheng, n = 3). The elimination kinetics of PCDFs were concentration-dependent, with faster rates observed at higher concentrations and the apparent transition to slower rates occurring at about 1–3 ppb. Average half-lives of 1.1, 2.3, and 1.5 years above the transition concentration and 7.2, 5.7, and 3.5 years below it were estimated for 2,3,4,7,8-pentaCDF, 1,2,3,4,7,8-hexaCDF, and 1,2,3,4,6,7,8-heptaCDF, respectively. A positive linear correlation of half-life with age was observed for the combined group, with a rate of increase of 0.19, 0.12, and 0.05-year half-life per year of increase in age for penta-, hexa-, and hepta-CDF, respectively. The distinctly younger Yucheng patients exhibited far lower variability in half-lives and age-related trends that were quite consistent with the corresponding data on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for younger persons exposed in the Seveso incident. These age- and concentration-dependent half-lives for PCDFs may have important risk assessment implications for estimating body burdens. The current study provides limited additional evidence that PCDFs, like TCDD, are more rapidly eliminated in younger individuals.

Key Words: blood lipid dioxins • elimination half-life • human • ingestion exposure • PCDF • pharmacokinetics • rice cooking oil

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Toxicology and Industrial Health, Vol. 23, No. 8, 493-501 (2007)
DOI: 10.1177/0748233708089024


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Leung, H. Articles by Masuda, Y Search for Related Content PubMed PubMed Citation Articles by Leung, H. Articles by Masuda, Y Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB VEGETABLE OIL Social Bookmarking                         What's this?